Mannitol CAS NO.87-78-5

Preparation method

There are two main processes for industrial production of Mannitol in the world. One is kelp as raw material. During the production of alginate, kelp soaking solution after iodine extraction is obtained through repeated concentration, impurity removal, dissociation, evaporation concentration and cooling crystallization. One is derived from sucrose and glucose by hydrolysis, differential isomerization and enzyme isomerization, and then hydrogenation.

Mannitol extraction from kelp has been carried out for several decades in China. This process is simple and feasible, but its development has been restricted by raw material resources, extraction rate, climate conditions, energy consumption and so on. The annual output of Mannitol has not exceeded 8000 tons in the last century. Chinese synthetic technology began to be tested in the 1980s and came out in the 1990s. The time is not long, but because of its advantages such as not restricted by raw materials and suitable for mass production, it has made great progress.

Mannitol, chemical formula C6H14O6, is a sugar alcohol, is an isomer of sorbitol, soluble in water, white crystalline powder, has a sweet taste similar to sucrose.

Chemical formula: C6H14O6

Molecular weight: 182.172

CAS No. : 87-78-5

EINECS number: 201-770-2

Physical and chemical properties

Density: 1.596g/cm3

Melting point: 166-168℃

Boiling point: 494.9℃

Flash point: 292.5℃

Refractive index: 1.597

Appearance: white crystalline powder

Solubility: easily soluble in water, almost insoluble in ethanol and ether

Preparation method

There are two main processes for industrial production of Mannitol in the world. One is kelp as raw material. During the production of alginate, kelp soaking solution after iodine extraction is obtained through repeated concentration, impurity removal, dissociation, evaporation concentration and cooling crystallization. One is derived from sucrose and glucose by hydrolysis, differential isomerization and enzyme isomerization, and then hydrogenation.

Mannitol extraction from kelp has been carried out for several decades in China. This process is simple and feasible, but its development has been restricted by raw material resources, extraction rate, climate conditions, energy consumption and so on. The annual output of Mannitol has not exceeded 8000 tons in the last century. Chinese synthetic technology began to be tested in the 1980s and came out in the 1990s. The time is not long, but because of its advantages such as not restricted by raw materials and suitable for mass production, it has made great progress.

storage

Keep out of light and sealed.

Application

Mannitol is of stable properties. With its own unique physiological properties, mannitol is widely used in medicine, food and other industrial fields.

In medicine -- Mannitol is a good diuretic, it can be used to reduce intracranial pressure, intraocular pressure and to be as renal medicine, dehydrating agent, substitutes of sugar, etc. It can also be used as excipient of tablet and diluent agent of solid or liquid. As a hypotensor with high permeability, mannitol injection is commonly used in clinical rescue, particularly in brain disorders. It is of the characteristics of reducing pressure fast and accurate curative effect, which are what the drug of reducing intracranial pressure requires. As excipients of tablets, mannitol is non-hygroscopic, and of drying quickly, good chemical stability. It is also refreshing and easy to form particles. It can be used in most tablets such as anticancer drugs, antibiotics, antihistamines and vitamin, etc. In addition, it can be used in chewing tablets such as sobering up medicine and mouth refreshing agent, etc.

In food industries - The absorbency of mannitol in sugar and sugar alcohols is in minimum level. It is of refreshing sweet taste and used in the anti-adherence of food such as malt sugar, gum and rice cake etc, as well as used as adhesion-proof powders of general cake. It can also be used as low calorific value and low sugar content sweeteners like food and body-building food for diabetes patients.

In other industries -- Mannitol can be used in plastics industry to produce rosin ester, synthetic glycerol resin, explosives and detonators ( nitromannite ) etc. It can also be applied to determinate boron in chemical analysis and as bacterial culture agent in biological test, etc.